Recently, a team led by Wu Chengtie and Chang Jiang, researchers of the Shanghai Institute of Ceramics, Chinese Academy of Sciences, for the first time put forward the idea of combining bone tissue engineering and photothermal therapy for the first time in the preparation of photothermal functionalization for the treatment and repair of bone tumor defects New advances have been made in the study of bioactive ceramic scaffolds. In this study, bio-ceramic and graphene oxide composite scaffolds were prepared by 3D printing technology. Under ultra-low power NIR, the scaffold temperature increased rapidly and its photothermal performance was controlled.
 
Implantation of the functionalized scaffold in vivo and illumination in mice effectively inhibited the growth of subcutaneous tumor in nude mice, while the volume of tumor in control group continued to increase with the number of days. At the same time, the scaffold can significantly promote the proliferation and osteogenic differentiation of mesenchymal stem cells and induce the growth of new bone tissue in vivo, thereby endowing the 3D printed bioceramic scaffold with anti-tumor and bone repair dual functions. Tumor treatment and repair has potential applications.
 
At present, the research results are accepted by Advanced Functional Materials (the first author of this dissertation is a doctoral candidate at Peabody). The reviewer spoke highly of the study: "This is a well-designed study with significant innovations that address the issue that traditional biological scaffolds do not combine both oncological treatment and bone repair." At present, the results have been filed A patent.
 
In addition, through three years of exploration, the research team successfully solved the problem that the controllability of the macropore size and the macropore structure of traditional 3D printing bioceramic scaffolds is not high. Recently, the group also successfully fabricated bioceramic scaffolds with multi-scale and complex structures using 3D printing methods, including hollow scaffolds of bioceramic hollow tubes and porous scaffolds of macropores-mesoporous composite materials. These new scaffold materials Well simulated human body complex structure, its osteogenic, vascularization performance was significantly improved.
Source: Medical innovation network